In PAD, there has been experimental studies with the modulation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), maternally expressed gene 3 (MEG3), antisense non-coding RNA in the INK4 locus (ANRIL), small nucleolar host gene 12 (SNHG12), and lncRNA [20]. This evidence concerns the gene MALAT1 and peripheral arterial disease.