POLD1 and neoplasm: In SebCA02, POLD1, DNM2, EPHA3, HISTH1D, HISTH2BO, RUNX1, ZNF703, and RAD51D alterations were also present in the primary tumor, while two ZFHX4 alterations were only identified in the cell line, and TP53 and MKI67 changes present in the primary tumors were not detected in the corresponding cultures.