In fact, immunohistochemical markers such as galectin-3, HBME-1 (Hector Battifora’s “Mesothelioma” 1), BRAF V600E, and p53 have been shown to be helpful in the diagnostic phase of thyroid nodules, particularly in distinguishing benign from malignant lesions. This evidence concerns the gene LGALS3 and thyroid nodule.