Binomial logistic regression analysis revealed that the CG genotype of STAT4 rs10181656 compared with the CC genotype increases the odds of LSCC with T1 tumor size occurrence by 2.4-fold (OR = 2.412, 95% CI: 1.522–3.822, p < 0.001) while under the overdominant model, the CG genotype increases these odds by 1.8-fold (OR = 1.780, 95% CI: 1.162–2.728, p = 0.008). Here, STAT4 is linked to neoplasm.