STAT4 rs10181656 CG + GG genotypes were found to be associated with increased odds of poorly differentiated LSCC by 2.3-fold under the dominant model (OR = 2.324, 95% CI: 1.653–3.269, p < 0.001), and each G allele of the rs10181656 is associated with 2.1-fold increased odds of developing LSCC with the T2 tumor size (OR = 2.087, 95% CI: 1.591–2.736, p < 0.001) (Table 17). This evidence concerns the gene STAT4 and neoplasm.