The results of the binomial logistic regression analysis showed that the CG genotype of STAT4 rs10181656 increases the odds of LSCC with T2 tumor size development by 3.6-fold (OR = 3.617, 95% CI: 1.993–6.565, p < 0.001) under the codominant model, while the CG genotype increases these odds by approximately 2.5-fold (OR = 2.456, 95% CI: 1.447–4.169, p < 0.001) under the overdominant model. Here, STAT4 is linked to neoplasm.