STAT4 and neoplasm: In our study, each T allele of STAT4 rs7574865 increases the odds of LSCC occurrence by 1.4-fold (p = 0.005).Examining the influence of the STAT4 rs7574865 variant on the clinical manifestations of LSCC, we found that the T allele increases the odds of early-stage disease by 1.5-fold, enlarges the odds of developing a T1-sized LSCC by 1.6-fold, provides 1.5-fold increased odds of the tumor not metastasizing to the neck lymph nodes, and raises the odds of a well-differentiated LSCC by 1.7-fold (p = 0.007, p = 0.009, p = 0.003, and p = 0.004, respectively).