Taken together, our results showed that, in LDLR KO mice, dietary sodium restriction increased body mass, glycemia, and insulin resistance, and adversely altered lipid metabolism by increasing triglyceridemia, LDL-C, and VLDL-TG and reducing HDL-C and HDL-TG, showing a pro-atherogenic lipid profile. This evidence concerns the gene LDLR and Insulin resistance.