AGT and obesity due to melanocortin 4 receptor deficiency: The results show that, through an endocrine positive feedback cycle, the increase in systemic ANG II concentration induces AGT expression in adipose tissue, making adipose tissue a prominent site of AGT, which may contribute to RAAS hyperactivity in obesity-associated dysfunctions and plays an important role in the pathogenesis of ANG II-related CVD [46].