ACACA and cholangiocarcinoma: It is worth noting that the pattern of global protein acetylation observed in the ND-646-treated cells and the ACC1-KD cells (Figure 2a,b) was distinct from that of the SAHA-treated cells (Figure 5a); hence, additional exploration is required to identify the differential protein acetylation in ACC1-deficient and KDAC-inhibitory CCA cells.