Notably, certain genetic polymorphisms in genes like Interleukin-1 beta (IL1B), interleukin 1 receptor antagonist (IL1RN), the Fc gamma receptor III subunit b (FcγRIIIb), vitamin D receptor (VDR), and Toll-like receptor 4 (TLR4) have been associated with aggressive periodontitis susceptibility, while others in IL1B, IL1RN, interleukin 6 (IL6), interleukin 10 (IL10), VDR, the cluster of differentiation 14 glycoprotein (CD14), TLR4, and and the matrix metalloprotease 1 (MMP-1) are linked to chronic periodontitis [13]. The gene discussed is IL1RN; the disease is periodontitis.