PLG and periodontal disorder: Studies have identified genes like the antisense non-coding RNA in the INK4 locus (ANRIL/CDKN2B-AS1), plasminogen (PLG), and the Calmodulin-binding transcription activator 1 (CAMTA1)/Vesicle-Associated Membrane Protein 3 (VAMP3) implicated in both periodontitis and coronary artery disease pathogenesis, shedding light on functional features and accounting for some missing heritability of periodontal disease [17].