Nevertheless, systematic reviews and meta-analyses have identified significant associations between genetic variants in genes like interleukin 1A (IL-1A), interleukin 1B (IL-1B), IL6, IL10, the matrix metalloprotease 3 (MMP-3), and matrix metalloprotease 9 (MMP-9) and periodontitis risk [16]. Here, IL1B is linked to periodontitis.