Our findings showing the upregulation of MICA/B and MR1 on the cell surface of CD34+ bone marrow cells when exposed to PHA and LPS, and to a lesser extent Ace6F, are consistent with this notion; however, given the technical limitations associated with the difficulty in obtaining HSPCs from patients with aplastic anemia due to the bone marrow destruction inherent to the disease, we were not able to prove experimentally this hypothesis. Here, CD34 is linked to idiopathic aplastic anemia.