Similarly, Pediaditakis and colleagues developed “The Substantia Nigra Brain-Chip”, which includes human iBMECs, pericytes, astrocytes, microglia, and induced dopaminergic neurons, to study alpha-synuclein (αSyn) aggregation in Parkinson’s disease (PD; Figure 2, panel (D) [156]). This evidence concerns the gene SNCA and Parkinson disease.