Several natural compounds from traditional medicine, such as the flavonoid glucoside icariin, Coffea arabica extract (CAE), sodium thiosulfate (STS), a homogenous polysaccharide from the herb Lonicera japonica, and another herbal formula called Angelica Yinzi, have all proven to alleviate inflammation in AD by downregulating the NLRP3 inflammasome [38,39,40,41,42]. Here, NLRP3 is linked to Alzheimer disease.