IFNG and Achalasia: Moreover, twelve biomarkers were significantly increased in type III compared with I and II achalasia, namely, TGF-ß2, IL-1ra, IL-2Ra, IL-18, MIG, IFN-γ, SDF-1a, Eotaxin, PDGF-BB, IP-10, MCP-1 and TRAIL [[77], Tables 3 and 4].