With this intent, Li et al. performed a sequencing-based exome-wide association study of achalasia in a Chinese population identifying and validating two independent common variants at the HLA region, rs1705003 cuta divalent cation tolerance homolog (CUTA) and rs1126511 (HLA-DPB1), and three rare and functional variants in cyclic AMP responsive element binding protein 5 (CREB5), extended synaptotagmin 3 (ESYT3) and lipin 1 (LPIN1) genes associated with an increased risk to develop idiopathic achalasia. The gene discussed is HLA-DPB1; the disease is Achalasia.