De la Concha et al. explored the presence of the HLA class II alleles and tumor necrosis factor-α (TNFα) and TNFβ microsatellites in patients with achalasia, observing that the TNFα11 allele and the DRB1*1501-DQA1*0102-DQB1*0602 haplotype were less common in patients, strengthening the possible relationship between the disease and the HLA-DQ1 allele and indicating that TNFα11 could be associated with protection from the pathology [34]. Here, TNF is linked to Achalasia.