Moreover, in LES of patients with achalasia, the hypophosphorylation of 20-kDa myosin light chains, a possible cause of impaired contractility, was associated with the myosin phosphatase-inhibitor protein CPI-17 down-regulation and with an increase in Th17-related cytokines, including IL-17A, IL-17F, IL-22 and IL-23A [63]. This evidence concerns the gene IL23A and Achalasia.