AKT2 and early-onset autosomal dominant Alzheimer disease: For example, miR-6842-5p is involved in glucose metabolism through the inhibition of AKT2 and has a negative effect on proliferation and migration in endothelial cells during persistent high-glucose exposure, and miR-661, one of the most promising miRNAs identified in this work, has been implicated in several types of cancer as well as some diseases, such as diabetes mellitus 2 and Alzheimer’s disease (see Table 5).