Patients with lower EM grades (i.e., grades 1 and 2) and those diagnosed up to 2 years before enrollment exhibited increased percentages of PF CD8+ CD56dimCD16Hi NK cells compared to controls (p = 0.033 for grade 1/2 patients; p = 0.008 for patients with <2 years of EM diagnosis). The gene discussed is CD8A; the disease is erythema multiforme.