Previous studies of the roles of miR-130b-3p and miR-423-5p in cancer progression have shown that miR-130b promotes cell growth and chemo-resistance by regulating the PTEN gene in lung cancer, renal cell carcinoma, and breast cancer [30,31,32], whereas miR-130b inhibits tumor migration and invasion in prostate cancer by suppressing the DLL1 and PI3K/Akt pathways [33]. Here, PTEN is linked to hereditary clear cell renal cell carcinoma.