GLA and Fabry disease: Fabry Disease (FD, OMIM #301500) is an X-linked lysosomal disease due to pathogenic variants in the GLA gene encoding for α-galactosidase A. It results in the accumulation of globotriaosylceramide (Gb3) and its deacetylated derivative (lyso-Gb3) in fluids and cellular lysosomes [1].