AGT and Alzheimer disease: Third, although Ang II and its receptors have not been identified in D. melanogaster [14], earlier studies reported that losartan, an angiotensin receptor blocker (ARB), significantly rescued memory deficits in a Drosophila model of Alzheimer’s disease (AD) [15] and improved mitochondrial morphology in indirect flight muscles of Drosophila mutants of Multiplexin, the ortholog of vertebrate collagen XV and XVII [16].