CD86 and diabetes mellitus: This screening revealed a total of 13 up-regulated GOIs related to diabetes, monocyte function, inflammation, cytokines/chemokines, and MMPs, including ZAP70, CD5, NLGN3, MAPK81P3, MAPK13, IL11RA, ZBTB17, TRAF1, TRPV1, ZBTB25, NFKB2, IRS2 and TRAF31P2-AS1 and 11 down-regulated genes, including EMB, CD86, TLR4, NCK1, CD244, CD1C, PALLD, DSC2, TGFA, CX3CR1, and PPBP (Figure 1).