NEFL and Alzheimer disease: Matsuoka et al. showed that there was a significant association between increased plasma NfL and a decreased Glu/tCr in the right dorsolateral prefrontal cortex of participants with AD dementia, and there was only a trend of association between elevated plasma NfL and decreased Glu/tCr in the posterior cingulate gyrus, but this correlation did not reach statistical significance [59].