SGCB and Familial prostate cancer: More recently, Zhang and colleagues have demonstrated that sGC signaling is targeted in the progression from castration-sensitive to castration-resistant prostate cancer cells by two mechanisms: initially by disrupting the stoichiometry of the sGC heterodimer via sGCβ1 loss in the former, followed by recovery of sGCβ1 expression but sGC oxidative inhibition in the latter.