sGCα1 and sGCβ1 expression was also shown to be specifically and directly regulated by transmembrane protease serine 2 (TMPRSS2):v-ets erythroblastosis virus E26 oncogene homolog (ERG), also known as TMPRSS2:ERG or T2E (TMPRSS2-ERG), in PCa prostate cancer cells. Here, TMPRSS2 is linked to Familial prostate cancer.