More recently, Zhang and colleagues have demonstrated that sGC signaling is targeted in the progression from castration-sensitive to castration-resistant prostate cancer cells by two mechanisms: initially by disrupting the stoichiometry of the sGC heterodimer via sGCβ1 loss in the former, followed by recovery of sGCβ1 expression but sGC oxidative inhibition in the latter. Here, SGCB is linked to prostate cancer.