The fact that OXGR1 is abundant in the kidney and that ORXG1 might determine PRR-dependent Ang II formation/Na+ reabsorption opens new important information that can be used to develop new drugs, therapeutic (novel OXGR1 inhibitors), and diagnostic approaches for the treatment of hypertension, cardiovascular, and kidney disease. The gene discussed is OXGR1; the disease is hypertensive disorder.