CCN4 and metabolic dysfunction-associated steatohepatitis: In another line of research, WISP1 in the context of non-alcoholic steatohepatitis (NASH)-associated chronic liver disease induced MRTF activation and enhanced myofibroblast gene expression related to cytoskeletal dynamics and motility via the integrins αVβ1/3/5/8 and α11β1 [116].