TGFB1 and asthma: Pharmacological inhibition of β-catenin/CBP interaction using the small molecule ICG-001 prevented smooth muscle remodeling and expression of ECM proteins in both in vitro and in vivo asthma models, while β-catenin signaling was necessary for TGF-β-induced expression of ECM proteins by human ASM cells and pulmonary fibroblasts [77].