Thus, RTSH due to TSHR variants may give different phenotypes, depending on whether TSHR function is unaffected, partially affected, or completely affected: fully compensated RTSH (euthyroid state, appropriate increase in TSH); partially compensated RTSH (mild/borderline hypothyroidism); or uncompensated RTSH (severe CH) [8], respectively. The gene discussed is TSHR; the disease is cyclic hematopoiesis.