ITGB2 and leukemia: In spite that these three leukemia human macrophage cells are not within the scope of our review, it is worth mentioning that these human cell lines showed structural disorganization of the cytoskeleton with a decrease in actin, tubulin, and vimentin [43,166,173,208] in addition to a significant reduction in the cell adhesion molecule ICAM-1 and CD18 expression.