Talin-1, another protein that mediates the linkage of integrin to the actin cytoskeleton, is necessary for its activation via integrin β1 and β3 [99,100] and is an essential biomarker for cancer [154], which facilitates platelet activation and thrombus formation, as mice with mutant L325R Talin-1 show increased bleeding times [104]. Here, TLN1 is linked to cancer.