The authors showed that Drosophila flies with increased soluble carbohydrate and glycogen levels presented with locomotor defects, and displayed decreased levels of tyrosine hydroxylase, a representative marker of dopaminergic neurons in the substantia nigra, as well as elevated markers of oxidative stress, also participating in the multifactorial pathogenesis of Parkinson’s disease [25,26]. The gene discussed is TH; the disease is Parkinson disease.