As shown above, NAC has not been repeatedly studied using uniform concentrations (literature reports range from 0.03% to 20%), routes of delivery (topical, intradermal injections or intraperitoneal), wound models (excisional, incisional or burn wound) and DM animal models (alloxan-induced, streptozotocin-induced or leptin-deficient). The gene discussed is LEP; the disease is diabetes mellitus.