KRAS and neoplasm: Because KC mice do not progress to pancreatic cancer and are mainly used to study inflammation in the context of Kras mutations, LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre (KPC) mice were used to test if I-BET-762 can reduce the expression of HO-1 in the pancreas before tumor formation.