We pinpointed 8 human-derived genes (PHF14, PELP1, RPL7L1, HPRT1, RELN, RNU1-75P, RNU5A-8P, RNVU1-19), likely to represent tumor-specific signals as a signature combining these genes demonstrated high accuracy in assessing therapy response. This evidence concerns the gene RNU5A-1 and neoplasm.