HOXA7, HOXA10 (regulates proliferation, migration, and invasion and is associated with a less aggressive tumor phenotype), HOXB7, HOXC6, HOXC10 (regulates oral tumorigenesis through Wnt-EMT signaling pathways and may play a pivotal role in metastasis in OSCC), HOXD10, and HOXD11 were upregulated in oral carcinoma; in patients with an added risk factor, HOXA10 was involved in transcriptional misregulation, contributing to the malignant phenotype in oral carcinoma [71]. This evidence concerns the gene HOXC6 and lip and oral cavity carcinoma.