SNAI1 and cancer: Conley et al. demonstrated that the use of tyrosine inhibitor kinases could duplicate the percentage of the CSCs in cancers that have developed resistance to these therapies [166]; this must be due to their slow replicating capacity [151], which drives metastatic phenotype through the induction of the EMT (through the snail one and snail two expressions; those are considered major EMT inducers).