Overexpression of S100A8 and A9 in several inflammatory diseases such as psoriasis, rheumatoid arthritis, osteoarthritis, obesity and Alzheimer’s disease reflects the pathological function of S100A8/9 and indicates that targeting these proteins may open new therapeutic options in inflammation-associated diseases [14,15,19]. The gene discussed is S100A8; the disease is obesity due to melanocortin 4 receptor deficiency.