The first situation (namely, aging) results in the deposition of wild-type TTR (wtTTR) fibrils, causing a condition known as “wild-type transthyretin amyloidosis” (ATTRwt) (which was previously called “senile systemic amyloidosis”) [28,30]. The gene discussed is TTR; the disease is Familial transthyretin-related amyloidosis.