Moreover, C9-L interacts with SMCR8 through its DENN (differentially expressed in normal cells and neoplasia) domain, and when the C9-L-SMCR8 complex associates with WDR41, it functions as a GTPase-activating protein potentially involved in membrane trafficking, including endolysosomal pathways and autophagy [36]. This evidence concerns the gene SMCR8 and neoplasm.