BCL2 and breast cancer: The mucus of the H. aspersa snail also showed cytotoxicity activity against breast cancer cells Hs578T via inducing necrosis and downregulating BcL2 expression and NF-κB [21], while the mucus fractions (>50 kDa) isolated from H. aspersa exhibited a slight anti-proliferative effect on breast cancer lines (MCF-7 and MDA-MB-231) [53].