Among the up-regulated proteins anoctamin, SCO-spondin, mucin 19 proteins, neurotrypsins, barrier-to-autointegration factor B, cytochrome P450 2B2, saposin B-type domain-containing protein, tetraspanin, deleted in malignant brain tumors protein, ferroxidase, allene oxide synthase-lipoxygenase protein, artichoke protein, histone H1, and numerous uncharacterized proteins were found. The gene discussed is PRSS12; the disease is brain cancer.