The elevated formation of inflammasomes, expression of IL-1β and IL-18, and excessive cleavage of GSDMD have been reported in amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) cases, indicating a crucial role for pyroptosis in the neuroinflammation and development of ALS [67,303,304]. This evidence concerns the gene IL18 and amyotrophic lateral sclerosis.