Barros-Viegas AT et al. [73] studied the role of miRNA-31 in improving cognition and abolishing Aβ pathology by targeting APP and BACE1 in an AD mice model, discovering that miR-31 was downregulated in patients with AD, and may concurrently lower the levels of APP and BACE1 mRNA in the hippocampal regions of AD mice. Here, APP is linked to Alzheimer disease.