PSEN1 and Alzheimer disease: The function and underlying molecular mechanisms of miR-200a-3p in mediating neuroprotection against AD-related impairments were studied by Wang L and colleagues [101]; miR-200a-3p expression was assessed in the hippocampal regions of APP/PS1 and SAMP8 mice, an in vitro model of AD, and in blood plasma from patients with AD.