In the presence of the prodrug ganciclovir (GCV), administration of RGD4C/AAVP-Grp78-HSVtk followed by TMZ showed greater in vitro tumor cell destruction of glioblastoma cells (from LN229, U87, and SNB19 cell lines) than solely phage therapy or TMZ therapy. The gene discussed is HSPA5; the disease is neoplasm.