SLC5A2 and pachyonychia congenita: Because nothing is known concerning the effect of the combination of metformin and SGLT2 inhibitors on PC, we decided to evaluate the effect of SGLT2 inhibitors (canagliflozin and dapagliflozin), separately and in combination with metformin, on several cancer-related characteristics of the PC cell lines AsPC-1 and PANC-1.