Research has shown that the PI3K-AKT signaling pathway, with AKT as the key protein, plays an important role in inhibiting viral infections [29,30]; therefore, combined with the results of KEGG enrichment analysis by 4D-LFQ proteomics, the PI3K-AKT signaling pathway and the apoptosis pathway were selected for subsequent studies. This evidence concerns the gene AKT1 and viral infectious disease.