Statistically, there were no differences between the Irf1 levels in the spleen samples from the lupus-treated and untreated groups, but Irf1 was 50% lower in the spleen from lpr_Spermidine (0.82 ± 0.56 a.u.)compared to the spleen from lpr_Control (1.79 ± 0.32 a.u.)(Figure 6A). The gene discussed is IRF1; the disease is systemic lupus erythematosus.