Ge et al. [70] developed an OAd that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and second mitochondria-derived activator of caspase (Smac) (ZD55-TRAIL-IETD-Smac) and evaluated its activity in pancreatic cancer models with a CDK inhibitor SNS-032. This evidence concerns the gene TNFSF10 and familial pancreatic carcinoma.