APP and Alzheimer disease: 7. Validation of the Notion That the Occurrence and Timing of Conventional AD Is a Function of the Rate of Accumulation of AβPP-Derived iAβ: All Known Mutations Either Causing AD or Protecting from AD as Well as Factors Predisposing to AD Act via Alterations of the Rate of Accumulation of AβPP-Derived iAβ