AKT1 and melanoma: Kaempferol was also proved to demonstrate significant antiproliferative effects on human malignant melanoma A375 cells, contributed to the reduction in colony formation in a dose-dependent manner, induced apoptosis, exhibited the capacity to trigger G2/M cell cycle arrest, suppressed the cell migratory potential of A375 cells and caused significant downregulation of the mammalian target of rapamycin (m-TOR), phosphorylated (p) m-TOR, phosphatidylinositol-3 kinase (PI3K) and phosphatidylinositol-3 kinase (PI3K)/Akt protein levels in A375 malignant melanoma cells [79].