IL6 and diabetic kidney disease: p-Coumaric was also evidenced to have a protective role against diabetic nephropathy through its anti-inflammatory and antioxidant properties [43], was proved to reduce TLR 4, IL-6 and TGF levels when applied at a dosage of 100 mg/kg body weight and increased phosphorylation of acetyl CoA carboxylase (ACC) as well as the expression of carnitine palmitoyltransferase-1 (CPT-mRNA) and peroxisome proliferator-activated receptor (PRAR), which may result in the elevated beta-oxidation of fatty acids and triacylglycerol synthesis [44].