Clària Dalli et al. (2012) further revealed that RvD1 and RvD2 decreased pro-inflammatory TNFα and IL-6 and increased adiponectin secretion in cell cultures of adipocytes and adipose tissue explants in a model of diet-induced obesity in mice [36]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.