Oncogenes, tumor suppressors, and proteins involved in tumor biology are also regulated by O-GlcNAc [43] such as phosphoglycerate kinase 1 (PGK1), enolase 1 (ENO1), glucose-6-phosphate dehydrogenase (G6PD) c-Myc, p53, Ras, AMPK, and NF-κB, among others. The gene discussed is PGK1; the disease is neoplasm.