TLR4 and neoplasm: On the other hand, platelets release proinflammatory cytokines that recruit and activate leukocytes [198] and growth factors that induce tumor growth and angiogenesis [199]; they also release P-selectin, which favors the formation of neutrophil extracellular traps (NETs) [200], while the release of Toll-like receptor 4 (TLR4) triggers NETosis in activated neutrophils [201].