AKT1 and cancer: The most studied pathways associated with O-GlcNAcylation are thrombosis, inflammation and cancer in the PI3K/Akt/c-Myc pathway [23], the nuclear factor-kappa B (NF-κB) signaling pathway [24,25], and PI3K/AKT/mTOR pathway [26,27] (Figure 3, modified of https://www.kegg.jp/pathway/map=map05200&keyword=cancer (accessed on 2 September 2024)).