YTHDF2 and nephritis: In our study, we found that 5mC was located upstream of m6A. A similar conclusion was obtained in a model of alcohol-induced nephritis, where the 5mC-related enzyme DNMT1 increased the methylation of the FTO GpG island, promoted FTO transcription, and reduced the m6A modification of PPAR-α and YTHDF2 induced RNA degradation [27].