However, NF-κB signaling modulation, in addition to the impact in trans on MDSCs, as reported here, can have a high negative side effect in cis on the fitness of T-ALL tumoral cells [23,49], as well as on other TME cell subsets, including MDSCs (see [57] and references therein), with a high risk to obtain confounding results from this kind of experiment. Here, NFKB1 is linked to acute lymphoblastic leukemia.