Second, though immature CD4+CD8+ DP T tumor cells are one of the most represented cell subsets in the spleen and bone marrow of N3tg/p50−/− young mice [49], we cannot exclude that other cell types (including MDSCs themselves) contribute to IL-6 production and release in the TME, thus sustaining the establishment of an immunosuppressive environment. This evidence concerns the gene NFKB1 and neoplasm.