IL6 and neoplasm: We observed an increase in p65 binding to both Site 1 and Site 3 in tumor DP T-cells from N3tg mice, that is in line with the constitutive activation of the NF-κB canonical pathway, originally described in tumor T-cells from the N3tg transgenic model [23], as well as with the significant increase in IL-6 protein levels described before with respect to their wt counterparts (see Figure 3B, above).