Instead, the increase in the NF-κB/p65 binding to the IL-6 promoter observed in DP T-ALL cells from N3tg mice (Figure 4C, middle panel, #2) stimulates the transcription of IL-6 and its release in the TME, sustaining the differentiation of functional MDSCs. Here, NFKB1 is linked to acute lymphoblastic leukemia.