We previously demonstrated that the deregulated activation of Notch3 inside thymocytes and malignant T-cells of our N3tg transgenic murine model of T-ALL induces the constitutive activation of the NF-κB complex, mainly represented by the p50/p65 heterodimers, via IKKα-dependent degradation of IκBα. This evidence concerns the gene RELA and acute lymphoblastic leukemia.