Thus, CHUK, IKBKB gene products, and co-chaperones FKBP5 (FKBP51), TSC1, and TSC2 interact with Hsp90 and behave like tumor suppressors, while AKT1 shows oncogenic behavior and is involved in the enhanced activity of many signaling pathways. This evidence concerns the gene FKBP5 and neoplasm.