RET and primary cutaneous amyloidosis: Regardless of the synchronous/asynchronous identification of MEN2 or confirmation of RET pathogenic variants at screening genetic testing on one patient, the diagnosis of PLCA should be confirmed by the histological exam in daily practice, whereas the deposition of eosinophil, amorphous globular material in the papillary dermis, melanophages, and increased pigmentation of the basal layer are typically observed [114].