Hemangioma endothelial cells in all phases express the pan-endothelial markers CD31/PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) and GLUT1, a glucose transporter normally present in the microvascular endothelium of the blood-brain barrier, retina, placenta, and red blood cell membrane, but not in normal skin [11,12,13]. This evidence concerns the gene PECAM1 and hemangioma.